Amino acid formula with vitamins and minerals without valine, leucine, isoleucine, supplemented with arachidonic acid and docosahexaenoic acid

PBAC's latest decision on Amino acid formula with vitamins and minerals without valine, leucine, isoleucine, supplemented with arachidonic acid and docosahexaenoic acid: Recommended (2023). Considered for Dietary management of maple syrup urine disease (MSUD) in infants and young children from 6 months to 5 years of age.

Eligible population

Infants and young children aged 6 months to 5 years with maple syrup urine disease (MSUD) requiring dietary management.

Therapy area

Metabolic

Line of therapy

Any

Evidence base

Cost-minimisation

Primary endpoint

Cost-minimisation

Comparator

MSUD gel (primary comparator); MSUD cooler10 and MSUD Anamix Junior/MSUD Anamix Junior LQ (secondary comparators)

Economic model

Cost-minimisation

Eligible patients/year

1

ICER note

Cost-minimisation analysis; no ICER calculated. MSUD explore5 was cost-minimised to comparators at equivalent price per gram of protein equivalent ($1.33 per gram PE).

Similar precedents

• Amino acid formula with vitamins and minerals without valine, leucine and isoleucine
  similarity 0.92
• Amino acid formula with fat, carbohydrate, without valine, leucine and isoleucine
  similarity 0.81
• Amino acid formula with vitamins and minerals (three formulations: without phenylalanine; without phenylalanine and tyrosine; without valine, leucine and isoleucine)
  similarity 0.74
• Amino acid formula with vitamins and minerals (msud, tyr, hcu coolers)
  similarity 0.73
• Amino acid formula with vitamins and minerals without methionine and supplemented with arachidonic acid and docosahexaenoic acid
  similarity 0.73
• Amino acid formula with vitamins and minerals, low phenylalanine and supplemented with docosahexaenoic acid and arachidonic acid
  similarity 0.72