Amino Acid Formula With Vitamins And Minerals Without Valine, Leucine, Isoleucine, Supplemented With Arachidonic Acid And Docosahexaenoic Acid

7.1 The PBAC recommended the General Schedule Restricted Benefit listing of amino acid formula with vitamins and minerals without valine, leucine, isoleucine and supplemented with arachidonic acid and docosahexaenoic acid (MSUD explore5) for the dietary management of maple syrup urine disease (MSUD) under the same circumstances as MSUD gel, except with a maximum quantity of 8 cartons rather than 4 cartons to provide the same number of grams of PE.PSD · Mar 2023

7.2 The PBAC considered that MSUD explore5 should be cost-minimised to the lowest cost comparator accepted by the NPWP (MSUD gel, MSUD Anamix Junior or MSUD Anamix Junior LQ) at an equivalent price per gram of PE.PSD · Mar 2023

5.10 The submission presented a cost-minimisation approach of MSUD explore5 compared with MSUD gel and MSUD cooler10, based on the same price per gram PE of $1.33 at the approved ex-manufacturer price (AEMP) (Table 3). 6PSD · Mar 2023

This has been updated here to $1598.52. a DPMQ as at 17 October 2022PSD · Mar 2023

5.7 The submission claimed non-inferior comparative effectiveness and non-inferior comparative safety of MSUD explore5 compared with MSUD gel. The submission provided a comparison of the nutritional profile of MSUD explore5 with MSUD gel presented as Table 2. 4PSD · Mar 2023

5.8 The PBAC advised MSUD explore5 is expected to provide a non-inferior clinical benefit for the management of MSUD compared to the comparators identified.PSD · Mar 2023