Amino Acid Formula With Vitamins And Minerals Without Methionine, Threonine And Valine And Low In Isoleucine

7.1 The PBAC recommended a General Schedule Restricted Benefit listing of amino acid formula with vitamins and minerals without methionine, threonine and valine and low in isoleucine, sachets containing oral powder 12.5 g, 30 (MMA/PA explore5™) for the dietary management of patients with a proven diagnosis of methylmalonic acidaemia (MMA) or propionic acidaemia (PA), under the same circumstances as the current listings for MMA/PA Anamix Junior and MMA/PA …PSD · Nov 2024

7.2 The PBAC considered that MMA/PA explore5 should be cost-minimised to the lowest cost comparator accepted by the NPWP (i.e., MMA/PA Anamix Junior and MMA/PA Anamix Infant) at an equivalent price per gram of protein equivalent.PSD · Nov 2024

5.9 The submission presented a cost-minimisation analysis of MMA/PA explore5 compared to MMA/PA Anamix Junior, based on the same cost per gram of PE. While MMA/PA Anamix Infant is also a main comparator, it was excluded from the economic analysis as the submission claimed MMA/PA Anamix Infant is an infant protein substitute whereas MMA/PA explore5 and MMA/PA Anamix Junior are ‘second-stage’ protein substitutes.PSD · Nov 2024

5.10 The protein equivalent content and proposed price of MMA/PA explore5, in comparison to MMA/PA Anamix Junior, are outlined in Table 2.PSD · Nov 2024

5.8 The submission claimed that MMA/PA explore5 is therapeutically comparable to MMA/PA Anamix Junior and MMA/PA Anamix Infant.PSD · Nov 2024