Amino Acid Formula With Vitamins And Minerals Without Methionine, Threonine And Valine And Low In Isoleucine
Recommended MetabolicRestrictedNot applicable line 💬 consumer voice
Dietary management of patients with a proven diagnosis of methylmalonic acidaemia (MMA) or propionic acidaemia (PA).
2
Submissions
2015–24
On the record
—
ICER range
Cost-min
Cost basis
Decision on record
- Meeting Nov 2024 Recommended Methylmalonic acidaemia; propionic acidaemia
Access path
- Nov 2015Recommended · restricted
vs MMA/PA Gel® and XMTVI Maxamaid®
- Nov 2024Recommended · restricted
Comparator changed: MMA/PA Gel® and XMTVI Maxamaid® → MMA/PA Anamix Junior and MMA/PA…
- PBS listing · Restricted
RecommendedDeferredNot recommended
From the public summary
PBAC outcome
7.1 The PBAC recommended a General Schedule Restricted Benefit listing of amino acid formula with vitamins and minerals without methionine, threonine and valine and low in isoleucine, sachets containing oral powder 12.5 g, 30 (MMA/PA explore5™) for the dietary management of patients with a proven diagnosis of methylmalonic acidaemia (MMA) or propionic acidaemia (PA), under the same circumstances as the current listings for MMA/PA Anamix Junior and MMA/PA …PSD · Nov 2024
7.2 The PBAC considered that MMA/PA explore5 should be cost-minimised to the lowest cost comparator accepted by the NPWP (i.e., MMA/PA Anamix Junior and MMA/PA Anamix Infant) at an equivalent price per gram of protein equivalent.PSD · Nov 2024
Economic analysis
5.9 The submission presented a cost-minimisation analysis of MMA/PA explore5 compared to MMA/PA Anamix Junior, based on the same cost per gram of PE. While MMA/PA Anamix Infant is also a main comparator, it was excluded from the economic analysis as the submission claimed MMA/PA Anamix Infant is an infant protein substitute whereas MMA/PA explore5 and MMA/PA Anamix Junior are ‘second-stage’ protein substitutes.PSD · Nov 2024
5.10 The protein equivalent content and proposed price of MMA/PA explore5, in comparison to MMA/PA Anamix Junior, are outlined in Table 2.PSD · Nov 2024
Clinical claim
5.8 The submission claimed that MMA/PA explore5 is therapeutically comparable to MMA/PA Anamix Junior and MMA/PA Anamix Infant.PSD · Nov 2024
Cost-effectiveness
Cost-minimisation analysis; no ICER calculated by design.
The PBAC considered that MMA/PA explore5 should be cost-minimised to the lowest cost comparator accepted by the NPWP (i.e., MMA/PA Anamix Junior and MMA/PA Anamix Infant) at an equivalent price per gram of protein equivalent. PBAC · 2024
Price cut / RSA neededCost-effectiveness accepted
Decision context
PopulationInfants and children aged six months to five years with a proven diagnosis of methylmalonic acidaemia (MMA) or propionic acidaemia (PA).
Submission history
| Decided | Outcome | Comparator | ICER | Evidence |
|---|---|---|---|---|
| Nov 2024 | Recommended · restricted | MMA/PA Anamix Junior and MMA/PA Anamix Infant | — | Cost-minimisation · Cost-minimisation |
| Nov 2015 | Recommended · restricted | MMA/PA Gel® and XMTVI Maxamaid® | — | Cost-minimisation · Cost-minimisation |
Consumer voice
No consumer comments were received for this item.
The PBAC noted that no consumer comments were received for this item. Consumer comments · PSD
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