Amino acid formula with vitamins and minerals without lysine and low in tryptophan

PBAC's latest decision on Amino acid formula with vitamins and minerals without lysine and low in tryptophan: Recommended (2024). Considered for Dietary management of patients with proven glutaric aciduria type 1 (GA-1) or pyridoxine dependent epilepsy (PDE).

Eligible population

Infants and children aged six months to five years with proven glutaric aciduria type 1 or pyridoxine dependent epilepsy requiring dietary management with a restricted protein diet (low lysine/low tryptophan).

Therapy area

Metabolic

Line of therapy

Not applicable

Evidence base

Cost-minimisation

Primary endpoint

Cost-minimisation

Comparator

GA gel (amino acid formula with vitamins and minerals without lysine and low in tryptophan sachets containing oral powder 24 g)

Economic model

Cost-minimisation

ICER note

Cost-minimisation analysis; no ICER calculated. GA explore5 is cost-minimised to GA gel at equivalent cost per gram of protein equivalent.

Submission history

• Mar 2015: Recommended · Restricted
• Nov 2015: Recommended with restriction · Restricted
• Nov 2020: Recommended with restriction · Restricted
• Nov 2024: Recommended · Restricted

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