Amino acid synthetic formula supplemented with long chain polyunsaturated fatty acids, medium chain triglycerides, 2'-fucosyllactose and lacto-n-neotetraose

PBAC's latest decision on Amino acid synthetic formula supplemented with long chain polyunsaturated fatty acids, medium chain triglycerides, 2'-fucosyllactose and lacto-n-neotetraose: Recommended with restriction (2022). Considered for Treatment of cows' milk protein enteropathy, severe cows' milk protein enteropathy with failure to thrive, combined intolerance to cows' milk protein, soy protein and protein hydrolysate formulae, cows' milk anaphylaxis, proven combined immunoglobulin E (IgE) mediated allergy to cows' milk protein and soy protein, severe intestinal malabsorption including short bowel syndrome, and eosinophilic oesophagitis.

Eligible population

Infants up to 24 months of age with cows' milk protein enteropathy, severe cows' milk protein enteropathy with failure to thrive, combined intolerance to cows' milk protein, soy protein and protein hydrolysate formulae, cows' milk anaphylaxis, proven combined IgE mediated allergy to cows' milk protein and soy protein, severe intestinal malabsorption including short bowel syndrome, or eosinophilic oesophagitis.

Therapy area

Metabolic

Line of therapy

First-line

Evidence base

RCT

Primary endpoint

Non-inferiority of weight gain

Key trials

CINNAMON (NCT03085134), Puccio 2017 (NCT01715246), PLATYPUS (NCT03661736)

Comparator

Alfamino (amino acid synthetic formula without HMO)

Economic model

Cost-minimisation

ICER note

Cost-minimisation analysis conducted; no ICER calculated. PBAC recommendation on cost-minimisation basis at same price as comparator Alfamino.

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