script.reportAU
Oncology

Nivolumab plus ipilimumab

Brand: Opdivo (nivolumab) and Yervoy (ipilimumab)

PBAC's latest decision on Nivolumab plus ipilimumab: Recommended with restriction (2020). Considered for First-line treatment of previously untreated Stage IV (metastatic) non-small cell lung cancer (NSCLC) in patients without EGFR or ALK gene rearrangements, in combination with platinum-based doublet chemotherapy.

PBAC outcome
Recommended with restriction
Restricted
ICER (AUD/QALY)
Cost-min
cost-minimisation analysis
Submissions
1
first 2020
Submissions
1
2020 → 2020

Eligible population

Adults with previously untreated Stage IV (metastatic) NSCLC without EGFR or ALK gene rearrangements, ECOG performance status 0 or 1, treated with nivolumab plus ipilimumab in combination with two cycles of platinum-based doublet chemotherapy.

Therapy area
Oncology
Line of therapy
First-line
Evidence base
RCT
Primary endpoint
OS
Pivotal trial size
719 patients
Key trials
CheckMate 9LA, Keynote 189, Keynote 407, IMpower150
Comparator
pembrolizumab plus platinum-based doublet chemotherapy
Economic model
Cost-minimisation
ICER note
Cost-minimisation analysis; no ICER calculated by design.

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