script.reportAU
Haematology

Daunorubicin with cytarabine

Brand: Vyxeos

PBAC's latest decision on Daunorubicin with cytarabine: Recommended with restriction (2023). Considered for Treatment of newly diagnosed therapy-related acute myeloid leukaemia (t-AML) or acute myeloid leukaemia with myelodysplasia-related changes (AML-MRC) in adults.

PBAC outcome
Recommended with restriction
Authority Required
ICER (AUD/QALY)
$75k/QALY
Range: $55k/QALY–$75k/QALY
Submissions
1
first 2023
Submissions
1
2023 → 2023

Eligible population

Adults with newly diagnosed therapy-related acute myeloid leukaemia or acute myeloid leukaemia with myelodysplasia-related changes, without prior chemotherapy for induction, excluding FLT3 mutation positive patients and those with favourable risk cytogenetics.

Therapy area
Haematology
Line of therapy
First-line
Evidence base
RCT
Primary endpoint
OS
Comparator
idarubicin plus cytarabine
Economic model
CUA
Eligible patients/year
1

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