Citrulline
Recommended MetabolicRestrictedNot applicable line 💬 consumer voice
Treatment of urea cycle disorders, specifically for preventing low plasma arginine or citrulline levels.
1
Submissions
2015–15
On the record
—
ICER range
Cost-min
Cost basis
Decision on record
- Meeting Nov 2015 Recommended Medicinal food
Access path
- Nov 2015Recommended · restricted
vs Citrulline 1000® powder sachets
- PBS listing · Restricted
RecommendedDeferredNot recommended
From the public summary
PBAC outcome
6.1 The PBAC recommended the listing of Citrulline Easy Tablets® as a Restricted Benefit for the treatment of urea cycle disorders on a cost-minimisation basis against Citrulline 1000® powder sachets at an equivalent price per gram of citrulline.PSD · Nov 2015
6.2 The PBAC noted that the advice from Nutritional Products Working Party. The PBAC considered that the wording of restrictions for this product and Citrulline 1000® powder sachets should be same. 2PSD · Nov 2015
Cost-effectiveness
Cost-minimisation analysis; nil cost to PBS estimated due to direct substitution at equivalent price per gram of citrulline.
The PBAC considered that the wording of restrictions for this product and Citrulline 1000® powder sachets should be same. PBAC · 2015
Cost-effectiveness accepted
Decision context
PopulationPatients with urea cycle disorders requiring citrulline supplementation.
Submission history
| Decided | Outcome | Comparator | ICER | Evidence |
|---|---|---|---|---|
| Nov 2015 | Recommended · restricted | Citrulline 1000® powder sachets | — | Cost-minimisation · Cost-minimisation |
Consumer voice
No consumer comments were received for this item.
The PBAC noted that no consumer comments were received for this item. Consumer comments · PSD
Similar precedents
Arginine76%Essential Amino Acids Formula With Vitamins And Minerals67%Amino Acid Formula With Fat, Carbohydrate Without Phenylalanine And Tyrosine67%Amino Acid Formula With Carbohydrate Without Phenylalanine66%Amino Acid Formula Without Phenylalanine65%Sodium Phenylbutyrate64%Amino Acid Formula With Fat, Carbohydrate, Vitamins And Minerals Without Phenylalanine63%Amino Acid Formula With Fat, Carbohydrate Without Methionine63%
Regulatory · TGA
Label narrower than PBS population — PBAC restricts to urea cycle disorders requiring citrulline supplementation; TGA label covers all foods for special medical purposes.