script.reportAU
Endocrinology

Saxagliptin

Brand: Onglyza

PBAC's latest decision on Saxagliptin: Recommended with restriction (2015). Considered for Treatment of patients with type 2 diabetes mellitus in combination with metformin and a sulfonylurea (triple oral therapy).

PBAC outcome
Recommended with restriction
Authority Required
ICER (AUD/QALY)
Cost-min
cost-minimisation analysis
Submissions
3
first 2010
Submissions
3
2010 → 2015

Eligible population

Adults with type 2 diabetes mellitus inadequately controlled on maximally tolerated doses of metformin and a sulfonylurea, with HbA1c >7% or blood glucose >10 mmol/L in >20% of tests over 2 weeks.

Therapy area
Endocrinology
Line of therapy
Third-line
Evidence base
RCT
Primary endpoint
HbA1c
Pivotal trial size
257 patients
Key trials
Trial D006, Russell-Jones 2009, Trial 115, Matthaei 2015
Comparator
dapagliflozin
Economic model
Cost-minimisation
ICER note
Cost-minimisation analysis; no ICER reported. Submission was assessed on cost-minimisation basis compared to insulin glargine, exenatide, and dapagliflozin.

Submission history

Similar precedents

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