script.reportAU
Cardiovascular

Olmesartan medoxomil, amlodipine, hydrochlorothiazide

Brand: Sevikar HCT

PBAC's latest decision on Olmesartan medoxomil, amlodipine, hydrochlorothiazide: Recommended (2013). Considered for Treatment of hypertension in patients whose blood pressure is not adequately controlled by two of the following: an angiotensin II receptor antagonist, a dihydropyridine calcium channel blocker, or a diuretic.

PBAC outcome
Recommended
Restricted
ICER (AUD/QALY)
Cost-min
cost-minimisation analysis
Submissions
1
first 2013
Submissions
1
2013 → 2013

Eligible population

Patients with hypertension whose blood pressure is not adequately controlled with two of the following: an angiotensin II receptor antagonist, a dihydropyridine calcium channel blocker, or a diuretic.

Therapy area
Cardiovascular
Line of therapy
Later-line
Evidence base
RCT
Primary endpoint
Seated diastolic blood pressure and seated systolic blood pressure reduction
Pivotal trial size
2,452 patients
Key trials
U301 (TRINITY), E105, Calhoun et al. 2009
Comparator
individual components given concomitantly (amlodipine, hydrochlorothiazide, olmesartan); Exforge HCT (amlodipine, hydrochlorothiazide, valsartan)
Economic model
Cost-minimisation
ICER note
Cost-minimisation analysis; no ICER calculated

Similar precedents

Open on full dashboard →