MethoxyfluranePENTHROX
For the relief of pain in wound dressings or trauma in patients aged 2-18 years where alternate treatments are unsuitable; and for use in an Emergency Drug (Doctor’s Bag) Supplies.
Decision on record
- Meeting Jul 2008 Recommended Pain in wound dressing
Access path
- TGA registered · PENTHROX
TGA label narrower than the PBS population
- Jul 2008Recommended · restricted
vs placebo
- PBS listing · Authority Required
Cost-effectiveness
ICER stated as 'less than $15,000 per responder' but this is not a numeric ICER in standard AUD/QALY bands and uses a non-standard outcome metric (responders rather than QALYs/LYs). Document does not provide a conventional ICER range.
The PBAC recommended the listing of methoxyflurane in the PBS Doctor's Bag Item List only on the basis of an acceptable incremental cost per extra paediatric responder with upper limb fracture. PBAC · 2008
Decision context
Populationpatients aged 2-18 years with upper limb fracture or venepuncture
Submission history
| Decided | Outcome | Comparator | ICER | Evidence |
|---|---|---|---|---|
| Jul 2008 | Recommended · restricted | placebo | — | RCT | Non-randomised studies · Pain relief |
Similar precedents
Regulatory · TGA
Label narrower than PBS population — PBAC restricts to ages 2-18 years and specifies wound dressings, trauma, fractures, venepuncture; TGA label includes all conscious haemodynamically stable trauma patients without age limit.