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Haematology

Deferasirox

Brand: Deferasirox Juno

PBAC's latest decision on Deferasirox: Recommended (2020). Considered for Chronic iron overload due to disorders of haemopoiesis, including transfusion-dependent malignant and non-malignant disorders of erythropoiesis, and non-transfusion-dependent thalassaemia.

PBAC outcome
Recommended
Restricted
ICER (AUD/QALY)
Cost-min
cost-minimisation analysis
Submissions
5
first 2006
Submissions
5
2006 → 2020

Eligible population

Patients with chronic iron overload due to disorders of haemopoiesis: transfusion-dependent malignant disorders of haemopoiesis with median life expectancy exceeding five years; transfusion-dependent non-malignant disorders of erythropoiesis; and non-transfusion-dependent thalassaemia.

Therapy area
Haematology
Line of therapy
Any
Evidence base
Single-arm
Primary endpoint
Bioequivalence
Key trials
ECLIPSE
Comparator
Jadenu (deferasirox 90 mg, 180 mg, 360 mg film coated tablets)
Economic model
Cost-minimisation
ICER note
Cost-minimisation analysis; no ICER calculated as the submission was on a cost-minimisation basis with Jadenu as comparator.
ICER (historical)
$15k/QALY–$45k/QALY across 2 submissions (2006–2014) — the latest submission carried no numeric base case. No single PSD states this combined range; see source PSDs.
Risk sharing
Risk-sharing arrangement in place — Special Pricing Arrangements (SPA) apply to the listing, as noted in the administrative advice sections for each restriction.

Submission history

Similar precedents

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