Amlodipine With Valsartan And Hydrochlorothiazide
Recommended · restricted CardiovascularRestrictedNot applicable line
Hypertension in patients not adequately controlled with any two of the drugs in the combination.
1
Submissions
2010–10
On the record
—
ICER range
Cost-min
Cost basis
Access path
- Jul 2010Recommended · restricted
vs amlodipine, valsartan and hydrochlorothiazide given…
- PBS listing · Restricted
RecommendedDeferredNot recommended
Cost-effectiveness
Cost-minimisation analysis; no ICER calculated.
The PBAC accepted that the triple combination was superior to all three dual combinations of its components in reducing blood pressure (Study 2302) and bioequivalent to the three individual components taken concomitantly on a cost-minimisation basis compared with the constituent components at equivalent doses. PBAC · 2010
Decision context
PopulationPatients with hypertension not adequately controlled with any two of the three drugs (amlodipine, valsartan, hydrochlorothiazide) in the combination.
Submission history
| Decided | Outcome | Comparator | ICER | Evidence |
|---|---|---|---|---|
| Jul 2010 | Recommended · restricted | amlodipine, valsartan and hydrochlorothiazide given concomitantly as individual or combination therapies | — | RCT |